Study the contribution of immune cells to autoimmunity

We have 2 main aims (graphical abstract):

Aim 1: Integrative analysis of B and T cell subsets, BCR/TCR, and autoAb repertoires in AID. We will deeply phenotype B and T cell subsets in both healthy individuals and AID patients, employing cutting-edge single-cell technologies to map their transcriptomic, proteomic, and epigenetic profiles. This data will be integrated into an immunomics model to better understand the diversity of B/T cell responses across different diseases.

Aim 2: Deciphering myeloid cell responses in target organ homeostasis disruption. Focusing on target organs like the synovial joint, we will explore the interactions between myeloid cells and other immune cells, using advanced techniques including scRNAseq and imaging mass cytometry coupled with systems biology and machine learning. Our goal is to identify myeloid cell subsets and interactions that contribute to disease progression, paving the way for new therapeutic targets.

Our overall objective is to understand disease heterogeneity and identify potential candidates for the development of personalized therapies and innovative strategies targeting tissue homeostasis disruption.