Restoring immune homeostasis through cell therapy and in vivo cell reprogramming

Lactate: an alternative pathway for the immunosuppressive properties of mesenchymal stem/stromal cells
Carolina Pradenas, Noymar Luque-Campos, Karina Oyarce, Rafael Contreras-Lopez, Felipe A Bustamante-Barrientos, Andrés Bustos, Felipe Galvez-Jiron , María Jesús Araya, Catalina Asencio, Raúl Lagos, Yeimi Herrera-Luna, Daouda Abba Moussa, Charlotte Nicole Hill , Eliana Lara-Barba, Claudia Altamirano, Alexander Ortloff, Yessia Hidalgo-Fadic, Ana María Vega-Letter, María de Los Ángeles García-Robles , Farida Djouad, Patricia Luz-Crawford, Roberto Elizondo-Vega
Stem Cell Res Ther. 2023 Nov 19;14(1):335. doi: 10.1186/s13287-023-03549-4.

g-NK cells from umbilical cord blood are phenotypically and functionally different than g-NK cells from peripheral blood
Fei Gao 1 2, Mauricio Campos Mora 2, Michael Constantinides 2, Loïs Coenon 2, Caroline Multrier 2, Loïc Vaillant 2, Tianxiang Zhang 3, Martin Villalba
Oncoimmunology 2023 Nov 22;12(1):2283353. doi: 10.1080/2162402X.2023.2283353.

Cytokines impact natural killer cell phenotype and functionality against glioblastoma in vitro
Minna Sivonen, Katja A Sirviö, Sara Wojciechowski, Anssi Kailaanmäki, Satu Kaipainen, Aubrey Bailey, Martin Villalba, Tuija Kekarainen
Front Immunol. 2023 Sep 28:14:1227064. doi: 10.3389/fimmu.2023.1227064.

Dynamic Changes in miRNA Expression during the Generation of Expanded and Activated NK Cells
Chantal Reina-Ortiz, Ma Pilar Mozas, David Ovelleiro, Fei Gao, Martín Villalba
Int J Mol Sci. 2023 Aug 31;24(17):13556. doi: 10.3390/ijms241713556.

Transfer of mesenchymal stem cell mitochondria to CD4+ T cells contributes to repress Th1 differentiation by downregulating T-bet expression
Waseem Akhter , Jean Nakhle, Loïc Vaillant, Geneviève Garcin, Cécile Le Saout, Matthieu Simon, Carole Crozet, Farida Djouad, Christian Jorgensen, Marie-Luce Vignais, Javier Hernandez
Stem Cell Res Ther. 2023 Jan 24;14(1):12. doi: 10.1186/s13287-022-03219-x.

PPAR β/ δ-Interfering Peptide Enhanced Mesenchymal Stromal Cell Immunoregulatory Properties
Gautier Tejedor, Prisca Boisguerin, Éric Vivès, Christian Jorgensen, Jérôme Guicheux, Claire Vinatier, Claire Gondeau, Farida Djouad
Stem Cells Int. 2022 Dec 13:2022:5494749. doi: 10.1155/2022/5494749

Size-tunable lipid vectors for controlled local delivery of siRNA from gene activated matrix
Jeremy Salvador, Jade Berthelot, Claire Bony, Baptiste Robin, Josephine Lai Kee Him, Danièle Noël, Emmanuel Belamie, Marie Morille
Acta Biomater. 2022 Nov:153:97-107. doi: 10.1016/j.actbio.2022.09.016.

From CD16a Biology to Antibody-Dependent Cell-Mediated Cytotoxicity Improvement
Loïs Coënon, Martin Villalba
Front Immunol. 2022 Jun 3:13:913215. doi: 10.3389/fimmu.2022.913215.

Intra-articular delivery of full-length antibodies through the use of an in situ forming depot
Alexis Fayd’herbe De Maudave, Wilhem Leconet, Karine Toupet, Michael Constantinides, Guillaume Bossis, Marion de Toledo, Jérôme Vialaret, Christophe Hirtz, Adolfo Lopez-Noriega, Christian Jorgensen, Daniele Noël, Pascale Louis-Plence, Sylvestre Grizot, Martin Villalba
J Control Release 2022 Jan:341:578-590. doi: 10.1016/j.jconrel.2021.12.010.

Human MuStem cells repress T-cell proliferation and cytotoxicity through both paracrine and contact-dependent pathways
Marine Charrier, Judith Lorant, Rafael Contreras-Lopez, Gautier Téjédor, Christophe Blanquart, Blandine Lieubeau, Cindy Schleder, Isabelle Leroux, Sophie Deshayes, Jean-François Fonteneau, Candice Babarit, Antoine Hamel, Armelle Magot, Yann Péréon, Sabrina Viau, Bruno Delorme, Patricia Luz-Crawford, Guillaume Lamirault, Farida Djouad, Karl Rouger
Stem Cell Res Ther. 2022 Jan 10;13(1):7. doi: 10.1186/s13287-021-02681-3.

Metformin sensitizes leukemic cells to cytotoxic lymphocytes by increasing expression of intercellular adhesion molecule-1 (ICAM-1)
Nerea Allende-Vega, Joaquin Marco Brualla, Paolo Falvo, Catherine Alexia, Michael Constantinides, Alexis Fayd’herbe de Maudave, Lois Coenon, Delphine Gitenay, Giulia Mitola, Paul Massa, Stefania Orecchioni, Francesco Bertolini, Isabel Marzo, Alberto Anel, Martin Villalba
Sci Rep. 2022 Jan 25;12(1):1341. doi: 10.1038/s41598-022-05470-x.

Delivery of miR-146a to Ly6Chigh Monocytes Inhibits Pathogenic Bone Erosion in Inflammatory Arthritis
Meryem Ammari, Jessy Presumey, Clara Ponsolles, Gautier Roussignol, Christine Roubert, Virginie Escriou, Karine Toupet, Anne-Laure Mausset-Bonnefont, Maïlys Cren, Maxime Robin, Philippe Georgel, Ramzi Nehmar, Leonie Taams, Joachim Grün, Andrea Grützkau, Thomas Häupl, Yves-Marie Pers, Christian Jorgensen, Isabelle Duroux-Richard, Gabriel Courties, Florence Apparailly
Theranostics 2018 Nov 13;8(21):5972-5985. doi: 10.7150/thno.29313.

miR-125b controls monocyte adaptation to inflammation through mitochondrial metabolism and dynamics
Isabelle Duroux-Richard, Christine Roubert, Meryem Ammari, Jessy Présumey, Joachim R Grün, Thomas Häupl, Andreas Grützkau, Charles-Henri Lecellier, Valérie Boitez, Patrice Codogno, Johanna Escoubet, Yves-Marie Pers, Christian Jorgensen, Florence Apparailly
Blood 2016 Dec 29;128(26):3125-3136. doi: 10.1182/blood-2016-02-697003.

Nicotinamide phosphoribosyltransferase/visfatin expression by inflammatory monocytes mediates arthritis pathogenesis
Jessy Présumey, Gabriel Courties, Pascale Louis-Plence, Virginie Escriou, Daniel Scherman, Yves-Marie Pers, Hans Yssel, Jérôme Pène, Diego Kyburz, Steffen Gay, Christian Jorgensen, Florence Apparailly
Ann Rheum Dis. 2013 Oct;72(10):1717-24. doi: 10.1136/annrheumdis-2012-202403.

In vivo RNAi-mediated silencing of TAK1 decreases inflammatory Th1 and Th17 cells through targeting of myeloid cells
Gabriel Courties, Virginia Seiffart, Jessy Presumey, Virginie Escriou, Daniel Scherman, Jochen Zwerina, Gisela Ruiz, Natalia Zietara, Jadwiga Jablonska, Siegfried Weiss, Andrea Hoffmann, Christian Jorgensen, Florence Apparailly, Gerhard Gross
Blood 2010 Nov 4;116(18):3505-16. doi: 10.1182/blood-2010-02-269605.