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Workpackage 3 (WP3) aims to evaluate the efficacy and safety of therapies based on extracellular vesicles, RNA vectors and CAR-engineered cells in different models (organoids, mathematical models, induced or humanized in vivo models). Longitudinal monitoring of the transcriptomic, metabolic and chromatin organization of CAR-engineered cells will allow the identification of modulated target genes and pathways to predict the immune response.
Cartilage regeneration in zebrafish depends on Nrg1/ErbB signaling pathway
Dora Sapède, Sarah Bahraoui, Léa Abou Nassif, Audrey Barthelaix, Marc Mathieu, Christian Jorgensen, Farida Djouad
Front Cell Dev Biol. 2023 Apr 4:11:1123299. doi: 10.3389/fcell.2023.1123299.
Lactate metabolism coordinates macrophage response and regeneration in zebrafish
Candice Bohaud, Jholy De La Cruz, Claudia Terraza, Audrey Barthelaix, Béryl Laplace-Builhé, Christian Jorgensen, Yoan Arribat, Farida Djouad
Theranostics 2022 May 13;12(8):3995-4009. doi: 10.7150/thno.65235.
Exploring Macrophage-Dependent Wound Regeneration During Mycobacterial Infection in Zebrafish
Candice Bohaud, Matt D Johansen, Béla Varga, Rafael Contreras-Lopez, Audrey Barthelaix, Claire Hamela, Dora Sapède, Thierry Cloitre, Csilla Gergely, Christian Jorgensen, Laurent Kremer, Farida Djouad
Front Immunol. 2022 Mar 24:13:838425. doi: 10.3389/fimmu.2022.838425.
Intra-articular delivery of full-length antibodies through the use of an in situ forming depot
Alexis Fayd’herbe De Maudave, Wilhem Leconet, Karine Toupet, Michael Constantinides, Guillaume Bossis, Marion de Toledo, Jérôme Vialaret, Christophe Hirtz, Adolfo Lopez-Noriega, Christian Jorgensen, Daniele Noël, Pascale Louis-Plence, Sylvestre Grizot, Martin Villalba
J Control Release 2022 Jan:341:578-590. doi: 10.1016/j.jconrel.2021.12.010.
Macrophage morphological plasticity and migration is Rac signalling and MMP9 dependant
Jana Travnickova, Sandra Nhim, Naoill Abdellaoui, Farida Djouad, Maï Nguyen-Chi, Andrea Parmeggiani, Karima Kissa
Sci Rep. 2021 May 12;11(1):10123. doi: 10.1038/s41598-021-88961-7.
NRG1/ErbB signalling controls the dialogue between macrophages and neural crest-derived cells during zebrafish fin regeneration
Béryl Laplace-Builhé, Audrey Barthelaix, Said Assou, Candice Bohaud, Marine Pratlong, Dany Severac, Gautier Tejedor, Patricia Luz-Crawford, Mai Nguyen-Chi, Marc Mathieu, Christian Jorgensen, Farida Djouad
Nat Commun. 2021 Nov 3;12(1):6336. doi: 10.1038/s41467-021-26422-5.
Regulatory T cell differentiation is controlled by αKG-induced alterations in mitochondrial metabolism and lipid homeostasis
Maria I Matias, Carmen S Yong, Amir Foroushani, Chloe Goldsmith, Cédric Mongellaz, Erdinc Sezgin, Kandice R Levental, Ali Talebi, Julie Perrault, Anais Rivière, Jonas Dehairs, Océane Delos, Justine Bertand-Michel, Jean-Charles Portais, Madeline Wong, Julien C Marie, Ameeta Kelekar, Sandrina Kinet, Valérie S Zimmermann, Ilya Levental, Laurent Yvan-Charvet, Johannes V Swinnen, Stefan A Muljo 3, Hector Hernandez-Vargas, Saverio Tardito, Naomi Taylor, Valérie Dardalhon
Cell Rep. 2021 Nov 2;37(5):109911. doi: 10.1016/j.celrep.2021.109911.
Mesenchymal stromal cells-derived extracellular vesicles alleviate systemic sclerosis via miR-29a-3p
Pauline Rozier, Marie Maumus, Alexandre Thibault, Jacques Maria, Karine Toupet, Joséphine Lai-Kee-Him, Christian Jorgensen, Philippe Guilpain, Danièle Noël
J Autoimmun. 2021 Jul:121:102660. doi: 10.1016/j.jaut.2021.102660.
Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells
Chamutal Bornstein, Shir Nevo, Amir Giladi, Noam Kadouri, Marie Pouzolles, François Gerbe, Eyal David, Alice Machado, Anna Chuprin, Beáta Tóth, Ori Goldberg, Shalev Itzkovitz, Naomi Taylor, Philippe Jay, Valérie S Zimmermann, Jakub Abramson, Ido Amit
Nature. 2018 Jul;559(7715):622-626. doi: 10.1038/s41586-018-0346-1.
Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis
Stella Cosenza, Karine Toupet, Marie Maumus, Patricia Luz-Crawford, Olivier Blanc-Brude, Christian Jorgensen, Danièle Noël
Theranostics 2018 Feb 3;8(5):1399-1410. doi: 10.7150/thno.21072.
Cell surface Glut1 levels distinguish human CD4 and CD8 T lymphocyte subsets with distinct effector functions
Gaspard Cretenet, Isabelle Clerc, Maria Matias, Séverine Loisel, Marco Craveiro, Leal Oburoglu, Sandrina Kinet, Cédric Mongellaz, Valérie Dardalhon, Naomi Taylor
Sci Rep. 2016 Apr 12:6:24129. doi: 10.1038/srep24129.
Les autres groupes de travail pour mener à bien ce projet.
Restoring immune homeostasis through cell therapy and in vivo cell reprogramming
Deep Immunophenotyping and new biomarkers for better patient stratification
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Formulaire et plan
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