Workpackage

Bioproduction

Workpackage
Workpackage

Bioproduction

Objective : Develop cell production capacity for both research and clinical (GMP) grade cell-based advanced therapy medicinal products (ATMPs) to be used in the IHU clinical trials.

Bioproduction of cell or cell-derived ATMPs for clinical applications is a critical part of innovative clinical trials to treat auto-immune diseases. It relies on two cardinal features:

1) a specific cell product, genetically engineered, or modified with antibodies, mRNA or complex culture conditions, meeting specifications that can address unmet clinical applications,

2) a GMP-compliant production that ensures that the end product meets preset specifications, including a robust potency test, and that is produced in sterile, traceable and reproducible fashion. We will complement our bioproduction capacity with private and academic partnerships, including partners of the IHU.

WP Leader
John De Vos
Professor

6.1.1. Bioproduction for clinical trial to treat sclerodermia using CART CD19 (SCLEROCAR)

6.1.2. Bioproduction for clinical trial to treat rheumatoid arthritis using CAR Treg cells

6.1.3. Bioproduction for clinical trial to treat sclerodermia using CAR MSC

6.1.4. Bioproduction for clinical trial to treat rheumatoid arthritis and lupus using cord-blood derived NK cells armed with specific antibodies constructs

6.1.5. Bioproduction for clinical trial to treat rheumatoid arthritis using iPSC-derived NK cells armed with specific antibodies constructs

6.2. GMP manufacturing of MSC-EV.

6.3. GMP manufacturing of RNA

Academic and industrial partners
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